RT Journal Article
SR Electronic
T1 Dynamical Patterning Modules and Network Motifs as joint determinants of development: lessons from an aggregative bacterium
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 655381
DO 10.1101/655381
A1 Guzmán-Herrera, Alejandra
A1 Angel, Juan A. Arias Del
A1 Rivera-Yoshida, Natsuko
A1 Benítez, Mariana
A1 Franci, Alessio
YR 2020
UL http://biorxiv.org/content/early/2020/05/05/655381.abstract
AB Development and evolution are dynamical processes under the continuous control of organismic and environmental factors. Generic physical processes, associated with biological materials and certain genes or molecules, provide a morphological template for the evolution and development of organism forms. Generic dynamical behaviors, associated with recurring network motifs, provide a temporal template for the regulation and coordination of biological processes. The role of generic physical processes and their associated molecules in development is the topic of the Dynamical Patterning Module (DPM) framework. The role of generic dynamical behaviors in biological regulation is studied via the identification of the associated Network Motifs (NM). We propose a joint DPM-NM perspective on the emergence and regulation of multicellularity focusing on a multicellular aggregative bacterium, Myxococcus xanthus. Understanding M. xanthus development as a dynamical process embedded in a physical substrate provides novel insights into the interaction between developmental regulatory networks and generic physical processes in the evolutionary transition to multicellularity.Competing Interest StatementThe authors have declared no competing interest.