RT Journal Article
SR Electronic
T1 Immunodietica: interrogating the role of diet in autoimmune disease
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.05.05.079418
DO 10.1101/2020.05.05.079418
A1 Iosif M. Gershteyn
A1 Andrey A. Burov
A1 Brenda Y. Miao
A1 Vasco H. Morais
A1 Leonardo M. R. Ferreira
YR 2020
UL http://biorxiv.org/content/early/2020/05/07/2020.05.05.079418.abstract
AB Diet is an environmental factor in autoimmune disorders, where the immune system erroneously destroys one’s own tissues. Yet, interactions between diet and autoimmunity remain largely unexplored, particularly the impact of immunogenetics, one’s human leukocyte antigen (HLA) allele make-up, in this interplay. Here, we interrogated animals and plants for the presence of epitopes implicated in human autoimmune diseases. We mapped autoimmune epitope distribution across organisms and determined their tissue expression pattern. Interestingly, diet-derived epitopes implicated in a disease were more likely to bind to HLA alleles associated with that disease than to protective alleles, with visible differences between organisms with similar autoimmune epitope content. We then analyzed an individual’s HLA haplotype, generating a personalized heatmap of potential dietary autoimmune triggers. Our work uncovered differences in autoimmunogenic potential across food sources and revealed differential binding of diet-derived epitopes to autoimmune disease-associated HLA alleles, shedding light on the impact of diet on autoimmunity.Competing Interest StatementI.M.G. and L.M.R.F. received funding from Ajax Biomedical Foundation, a 501(c)(3) corporation.