RT Journal Article
SR Electronic
T1 Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.01.24.917898
DO 10.1101/2020.01.24.917898
A1 Pierre Luisi
A1 Angelina García
A1 Juan Manuel Berros
A1 Josefina M. B. Motti
A1 Darío Demarchi
A1 Emma Alfaro
A1 Eliana Aquilano
A1 Carina Argüelles
A1 Sergio Avena
A1 Graciela Bailliet
A1 Julieta Beltramo
A1 Claudio M. Bravi
A1 Mariela Cuello
A1 Cristina Dejean
A1 José Edgardo Dipierri
A1 Laura S. Jurado Medina
A1 José Luis Lanata
A1 Marina Muzzio
A1 María Laura Parolin
A1 Maia Pauro
A1 Paula B. Paz Sepúlveda
A1 Daniela Rodríguez Golpe
A1 María Rita Santos
A1 Marisol Schwab
A1 Natalia Silvero
A1 Jeremias Zubrzycki
A1 Virginia Ramallo
A1 Hernán Dopazo
YR 2020
UL http://biorxiv.org/content/early/2020/05/09/2020.01.24.917898.abstract
AB Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to perform population structure analyses at a sub-continental level. Concerning the Native American ancestry, we could identify four Native American components segregating in modern Argentinean populations. Three of them are also found in modern South American populations and are specifically represented in Central Andes, Central Chile/Patagonia, and Subtropical and Tropical Forests geographic areas. The fourth component might be specific to the Central Western region of Argentina, and it is not well represented in any genomic data from the literature. As for the European and African ancestries, we confirmed previous results about origins from Southern Europe, Western and Central Western Africa, and we provide evidences for the presence of Northern European and Eastern African ancestries.Author Summary The human genetic diversity in Argentina reflects demographic processes during which the European colonists invaded a territory where Native American populations were settled. During the colonial period, the slave trade also prompted many African people to move to Argentina. Little is known about the origins of these three continental ancestry components in Argentinean populations nowadays. Genotyping data for 87 admixed individuals throughout Argentina was generated and data from the literature was re-analyzed to shed light on this question. We confirmed that most of the European genetic ancestry comes from the South, although several individuals are related to Northern Europeans. We confirmed that the African origins in Argentina mainly trace back from Western and Central/Western regions, and we document some proportion of Eastern African origins poorly described before. As for the Native American ancestry, we identified that it can be divided into four main components that correspond to Central Chile/Patagonia, Subtropical and Tropical Forests, Central Andes and Central Western region of Argentina. In order to understand the specificity of the genetic diversity in Argentina, more effort is required to generate specific massive genomic knowledge at the local level.Competing Interest StatementPL provides consulting services to myDNAmap S.L. JMB and JZ are employed by Biocódices S.A; HD is the scientific director of Biocódices S.A. Biocodices provided support in the form of part-time employment salaries for authors HD, JMB and JZ. Neither Biocódices nor myDNAmap have made any decision in the design of the study, sampling biological material, the collection, and the analysis of the data. These companies have also not made any decision on the preparation and publication of the work. Biocódices provided inputs for DNA's sample extraction and access to computing cluster resources.