RT Journal Article SR Electronic T1 Endoglycan plays a role in axon guidance and neuronal migration by negatively regulating cell-cell adhesion JF bioRxiv FD Cold Spring Harbor Laboratory SP 425207 DO 10.1101/425207 A1 Thomas Baeriswyl A1 Alexandre Dumoulin A1 Martina Schaettin A1 Georgia Tsapara A1 Vera Niederkofler A1 Denise Helbling A1 Evelyn Avilés A1 Jeannine A. Frei A1 Nicole H. Wilson A1 Matthias Gesemann A1 Esther T. Stoeckli YR 2020 UL http://biorxiv.org/content/early/2020/05/11/425207.abstract AB Cell migration and axon guidance are important steps in the formation of neural circuits. Both steps depend on the interactions between cell surface receptors and molecules on cells along the pathway. In addition to cell-cell adhesion, these molecular interactions provide guidance information. The fine-tuning of cell-cell adhesion is an important aspect of cell migration, axon guidance, and synapse formation.Here, we show that Endoglycan, a sialomucin, plays a role in axon guidance and cell migration in the central nervous system. In the absence of Endoglycan, commissural axons failed to properly navigate the midline of the spinal cord. In the developing cerebellum, a lack of Endoglycan prevented migration of Purkinje cells and resulted in a stunted growth of the cerebellar lobes. Taken together, these results support the hypothesis that Endoglycan acts as a ‘lubricant’, a negative regulator of cell-cell adhesion, in both commissural axon guidance and Purkinje cell migration.Competing Interest StatementThe authors have declared no competing interest.