%0 Journal Article %A Steven M. Weisberg %A Nora S. Newcombe %A Anjan Chatterjee %T Everyday taxi drivers: Do better navigators have larger hippocampi? %D 2018 %R 10.1101/431155 %J bioRxiv %P 431155 %X Work with non-human animals and human navigation experts (London taxi drivers) suggests that the size of the hippocampus, particularly the right posterior hippocampus in humans, relates to navigation expertise. Similar observations, sometimes implicating other sections of the hippocampus, have been made for aging populations and for people with neurodegenerative diseases that affect the hippocampus. These data support the hypothesis that hippocampal volume relates to navigation ability. However, the support for this hypothesis is mixed in healthy, young adults, who range widely in their navigation ability. Here, we administered a naturalistic navigation task that measures cognitive map accuracy to a sample of 90 healthy, young adults who also had MRI scans. Using a sequential analysis design with a registered analysis plan, we did not find that navigation ability related to hippocampal volume (total, right only, right posterior only). We conclude that navigation ability in a typical population does not correlate with variations in hippocampal size, and consider possible explanations for this null result. %U https://www.biorxiv.org/content/biorxiv/early/2018/09/29/431155.full.pdf