RT Journal Article SR Electronic T1 Neurodegeneration-related beta-amyloid as autocatabolism-attenuator in a micro-in vivo system JF bioRxiv FD Cold Spring Harbor Laboratory SP 2020.04.27.063115 DO 10.1101/2020.04.27.063115 A1 Evelin Balazs A1 Zita Galik-Olah A1 Bence Galik A1 Zsolt Bozso A1 Janos Kalman A1 Zsolt Datki YR 2020 UL http://biorxiv.org/content/early/2020/05/12/2020.04.27.063115.abstract AB Investigation of human neurodegeneration-related aggregates of beta-amyloid 1-42 (Aβ42) on bdelloid rotifers is a novel interdisciplinary approach in life sciences. We reapplied an organ size-based in vivo monitoring system, exploring the autocatabolism-related alterations evoked by Aβ42, in a glucose-supplemented starvation model. The experientially easy-to-follow size reduction of the bilateral reproductive organ (germovitellaria) in fasted rotifers was rescued by Aβ42, serving as a nutrient source- and peptide sequence-specific attenuator of the organ shrinkage phase and enhancer of the regenerative one including egg reproduction. Recovery of the germovitellaria was significant in comparison with the greatly shrunken form. In contrast to the well-known neurotoxic Aβ42 (except the bdelloids) with specific regulatory roles, the artificially designed scrambled version (random order of amino acids) was inefficient in autocatabolism attenuation, behaving as negative control. This native Aβ42-related modulation of the ‘functionally reversible organ shrinkage’ can be a potential experiential and supramolecular marker of autocatabolism in vivo.Competing Interest StatementThe authors have declared no competing interest.