RT Journal Article SR Electronic T1 CRISPR Artificial Splicing Factors JF bioRxiv FD Cold Spring Harbor Laboratory SP 431064 DO 10.1101/431064 A1 Nathaniel Jillette A1 Albert Cheng YR 2018 UL http://biorxiv.org/content/early/2018/09/30/431064.abstract AB We report here the engineering of CRISPR Artificial Splicing Factors (CASFx) based on an RNA-targeting CRISPR/Cas system. We showed that simultaneous exon inclusion and exclusion can be induced at distinct targets by differential positioning of CASFx. We also created inducible CASFx (iCASFx) using the FKBP-FRB chemical-inducible dimerization domain, allowing small molecule control of alternative splicing.