RT Journal Article
SR Electronic
T1 Sensorimotor hallucinations in Parkinson’s disease
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.05.11.054619
DO 10.1101/2020.05.11.054619
A1 Fosco Bernasconi
A1 Eva Blondiaux
A1 Jevita Potheegadoo
A1 Giedre Stripeikyte
A1 Javier Pagonabarraga
A1 Helena Bejr-Kasem
A1 Michela Bassolino
A1 Michel Akselrod
A1 Saul Martinez-Horta
A1 Fred Sampedro
A1 Masayuki Hara
A1 Judit Horvath
A1 Matteo Franza
A1 Stéphanie Konik
A1 Matthieu Bereau
A1 Joseph-André Ghika
A1 Pierre R. Burkhard
A1 Dimitri Van De Ville
A1 Nathan Faivre
A1 Giulio Rognini
A1 Paul Krack
A1 Jaime Kulisevsky
A1 Olaf Blanke
YR 2020
UL http://biorxiv.org/content/early/2020/05/12/2020.05.11.054619.abstract
AB Hallucinations in Parkinson’s disease (PD) are one of the most disturbing non-motor symptoms, affect half of the patients, and constitute a major risk factor for adverse clinical outcomes such as psychosis and dementia. Here we report a robotics-based approach, enabling the induction of a specific clinically-relevant hallucination (presence hallucination, PH) under controlled experimental conditions and the characterization of a PD subgroup with enhanced sensorimotor sensitivity for such robot-induced PH. Using MR-compatible robotics in healthy participants and lesion network mapping analysis in neurological non-PD patients, we identify a fronto-temporal network that was associated with PH. This common PH-network was selectively disrupted in a new and independent sample of PD patients and predicted the presence of symptomatic PH. These robotics-neuroimaging findings determine the behavioral and neural mechanisms of PH and reveal pathological cortical sensorimotor processes of PH in PD, identifying a more severe form of PD associated with psychosis and cognitive decline.Competing Interest StatementThe authors have declared no competing interest.