PT  - JOURNAL ARTICLE
AU  - Elisa Galliano
AU  - Christiane Hahn
AU  - Lorcan Browne
AU  - Paula R. Villamayor
AU  - Matthew S. Grubb
TI  - Brief sensory deprivation triggers cell type-specific structural and functional plasticity in olfactory bulb neurons
AID  - 10.1101/2020.05.10.086926
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.05.10.086926
4099  - http://biorxiv.org/content/early/2020/05/12/2020.05.10.086926.short
4100  - http://biorxiv.org/content/early/2020/05/12/2020.05.10.086926.full
AB  - Can alterations in experience trigger different plastic modifications in neuronal structure and function, and if so, how do they integrate at the cellular level? To address this question, we interrogated circuitry in the mouse olfactory bulb responsible for the earliest steps in odour processing. We induced experience-dependent plasticity in mice by blocking one nostril for a day, a minimally-invasive manipulation which leaves the sensory organ undamaged and is akin to the natural transient blockage suffered during common mild rhinal infections. We found that such brief sensory deprivation produced structural and functional plasticity in one highly specialised bulbar cell type: axon-bearing dopaminergic neurons in the glomerular layer. After 24h naris occlusion, the axon initial segment (AIS) in bulbar dopaminergic neurons became significantly shorter, a structural modification that was also associated with a decrease in intrinsic excitability. These effects were specific to the AIS-positive dopaminergic subpopulation, because no experience-dependent alterations in intrinsic excitability were observed in AIS-negative dopaminergic cells. Moreover, 24h naris occlusion produced no structural changes at the AIS of bulbar excitatory neurons – mitral/tufted and external tufted cells – nor did it alter their intrinsic excitability. By targeting excitability in one specialised dopaminergic subpopulation, experience-dependent plasticity in early olfactory networks might act to fine-tune sensory processing in the face of continually fluctuating inputs.Competing Interest StatementThe authors have declared no competing interest.