RT Journal Article
SR Electronic
T1 Layer-specific ultra-high field 7T fMRI showing that threat anticipation is mediated by the pulvinar input to the superficial layers of primary visual cortex (V1)
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 431270
DO 10.1101/431270
A1 Ai Koizumi
A1 Minye Zhan
A1 Hiroshi Ban
A1 Ikuhiro Kida
A1 Federico de Martino
A1 Beatrice de Gelder
A1 Kaoru Amano
YR 2018
UL http://biorxiv.org/content/early/2018/10/02/431270.abstract
AB The perceptual system gives priority to threat-relevant signals with survival value. Its mechanism may not only include the processing initiated in the presence of threat signals but also in the mere anticipation of such signals. Here, we show that the pulvinar modulates activity in the early visual cortex (V1) specifically in threat anticipation. Using ultra-high-field 7T fMRI, we examined the layer-specific interaction between V1 and the pulvinar, while taking advantage of the fact that the directionality of such interaction is anatomically constrained in specific V1 layers. Only in anticipation of a fearful face target, but not of a control happy face target, was false perception of anticipated-yet-unpresented target face accompanied by stronger activity in the V1 superficial-cortical-depth (layers 1-3), which was preceded by pre-target-onset pulvinar activity. The pulvinar may contribute to the visual processing initiated in the anticipation of threat, and play an important role in anxiety.