PT  - JOURNAL ARTICLE
AU  - Jon Sánchez-Valle
AU  - Hector Tejero
AU  - José María Fernández
AU  - David Juan
AU  - Salvador Capella-Gutiérrez
AU  - Fatima Al-Shahrour
AU  - Rafael Tabarés-Seisdedos
AU  - Vera Pancaldi
AU  - Alfonso Valencia
TI  - Unveiling the molecular basis of disease co-occurrence: towards personalized comorbidity profiles
AID  - 10.1101/431312
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 431312
4099  - http://biorxiv.org/content/early/2018/10/03/431312.short
4100  - http://biorxiv.org/content/early/2018/10/03/431312.full
AB  - Comorbidity is an impactful medical problem that is attracting increasing attention in healthcare and biomedical research. However, little is known about the molecular processes leading to the development of a specific disease in patients affected by other conditions. We present a disease interaction network inferred from similarities in patients’ molecular profiles, which significantly recapitulates epidemiologically documented comorbidities, providing the basis for their interpretation at a molecular level. Furthermore, expanding on the analysis of subgroups of patients with similar molecular profiles, our approach discovers comorbidity relations not previously described, implicates distinct genes in such relations, and identifies drugs whose side effects are potentially associated to the observed comorbidities.