RT Journal Article
SR Electronic
T1 Unveiling the molecular basis of disease co-occurrence: towards personalized comorbidity profiles
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 431312
DO 10.1101/431312
A1 Jon Sánchez-Valle
A1 Hector Tejero
A1 José María Fernández
A1 David Juan
A1 Salvador Capella-Gutiérrez
A1 Fatima Al-Shahrour
A1 Rafael Tabarés-Seisdedos
A1 Vera Pancaldi
A1 Alfonso Valencia
YR 2018
UL http://biorxiv.org/content/early/2018/10/03/431312.abstract
AB Comorbidity is an impactful medical problem that is attracting increasing attention in healthcare and biomedical research. However, little is known about the molecular processes leading to the development of a specific disease in patients affected by other conditions. We present a disease interaction network inferred from similarities in patients’ molecular profiles, which significantly recapitulates epidemiologically documented comorbidities, providing the basis for their interpretation at a molecular level. Furthermore, expanding on the analysis of subgroups of patients with similar molecular profiles, our approach discovers comorbidity relations not previously described, implicates distinct genes in such relations, and identifies drugs whose side effects are potentially associated to the observed comorbidities.