RT Journal Article
SR Electronic
T1 Asymmetric transcallosal conduction delay leads to finer bimanual coordination
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.01.24.918102
DO 10.1101/2020.01.24.918102
A1 Marta Bortoletto
A1 Laura Bonzano
A1 Agnese Zazio
A1 Clarissa Ferrari
A1 Ludovico Pedullà
A1 Roberto Gasparotti
A1 Carlo Miniussi
A1 Marco Bove
YR 2020
UL http://biorxiv.org/content/early/2020/05/19/2020.01.24.918102.abstract
AB It has been theorized that hemispheric dominance and a more segregated information processing have evolved to overcome long conduction delay through the corpus callosum (TCD) but that this may still impact behavioral performance mostly in tasks requiring high timing accuracy. Nevertheless, a thorough understanding of the temporal features of interhemispheric communication is missing due to methodological shortcomings. Here, we show in the motor system that TCD can be measured from transcranial magnetic stimulation (TMS) -evoked potentials (TEPs): by integrating TEPs with diffusion tensor imaging (DTI) and peripheral measures of interhemispheric inhibition (i.e., the ipsilateral silent period-iSP), we show that P15 TEP component reflects TCD between motor areas. Importantly, we report that better bimanual coordination is achieved when TCD between motor areas is asymmetric. These results suggest that interhemispheric communication can be optimized through asymmetric connectivity, in which information transfer is faster from the dominant hemisphere to the non-dominant hemisphere.Competing Interest StatementThe authors have declared no competing interest.