PT - JOURNAL ARTICLE AU - Wenlong Jia AU - Chang Xu AU - Shuaicheng Li TI - Conjugate graph resolves the complex structures at the virus integration loci with NGS data AID - 10.1101/2020.05.17.100578 DP - 2020 Jan 01 TA - bioRxiv PG - 2020.05.17.100578 4099 - http://biorxiv.org/content/early/2020/05/19/2020.05.17.100578.short 4100 - http://biorxiv.org/content/early/2020/05/19/2020.05.17.100578.full AB - Oncovirus integration introduced local genome instability on host genomes, in terms of copy number changes and structural variations. We present an algorithm, which implements double-strand-aware conjugate graph, to construct the rearranged local genomic map at viral integration loci. Diverse simulation data tests prove the availability and credibility of our algorithm. Applications of the algorithm to whole genome sequencing data of cervical carcinomas support reliable biological investigation on human papillomavirus integrations.Competing Interest StatementThe authors have declared no competing interest.