RT Journal Article
SR Electronic
T1 Non-linear randomized Haseman-Elston regression for estimation of gene-environment heritability
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.05.18.098459
DO 10.1101/2020.05.18.098459
A1 Kerin, Matthew
A1 Marchini, Jonathan
YR 2020
UL http://biorxiv.org/content/early/2020/05/19/2020.05.18.098459.abstract
AB Gene-environment (GxE) interactions are one of the least studied aspects of the genetic architecture of human traits and diseases. The environment of an individual is inherently high dimensional, evolves through time and can be expensive and time consuming to measure. The UK Biobank study, with all 500,000 participants having undergone an extensive baseline questionnaire, represents a unique opportunity to assess GxE heritability for many traits and diseases in a well powered setting. We have developed a non-linear randomized Haseman-Elston (RHE) regression method applicable when many environmental variables have been measured on each individual. The method (GPLEMMA) simultaneously estimates a linear environmental score (ES) and its GxE heritability. We compare the method via simulation to a whole-genome regression approach (LEMMA) for estimating GxE heritability. We show that GPLEMMA is computationally efficient and produces results highly correlated with those from LEMMA when applied to simulated data and real data from the UK Biobank.Competing Interest StatementThe authors have declared no competing interest.