TY - JOUR T1 - Condensin II inactivation in interphase does not affect chromatin folding or gene expression JF - bioRxiv DO - 10.1101/437459 SP - 437459 AU - Nezar Abdennur AU - Wibke Schwarzer AU - Aleksandra Pekowska AU - Indra Alon Shaltiel AU - Wolfgang Huber AU - Christian H Haering AU - Leonid Mirny AU - François Spitz Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/10/07/437459.abstract N2 - Condensin complexes have been proposed to play a prominent role in interphase chromatin organization and control of gene expression. Here, we report that the deletion of the central condensin II kleisin subunit Ncaph2 in differentiated mouse hepatocytes does not lead to significant changes in chromosome organization or in gene expression. Both observations challenge current views that implicate condensin in interphase chromosomal domain formation and in enhancer-promoter interactions. Instead, we suggest that the previously reported effects of condensin perturbation may result from their structural role during mitosis, which might indirectly impact the re-establishment of interphase chromosomal architecture after cell division. ER -