RT Journal Article
SR Electronic
T1 Analyzing the impact of SARS CoV-2 on the human proteome
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.05.21.107912
DO 10.1101/2020.05.21.107912
A1 Ernesto Estrada
YR 2020
UL http://biorxiv.org/content/early/2020/05/21/2020.05.21.107912.abstract
AB The COVID-19 respiratory disease is caused by the novel coronavirus SARS-CoV-2, which uses the enzyme ACE2 to entry human cells. This disease is characterized by important damages at multi-organ level, partially due to the abundant expression of ACE2 in practically all human tissues. However, not every organ in which ACE2 is abundant is affected by SARS CoV-2, which suggests the existence of other multi-organ routes for transmitting the perturbations produced by the virus. We consider here diffusive processes through the protein-protein interaction (PPI) network of proteins targeted by SARS CoV-2 as such alternative route. We found a subdiffusive regime that allows the propagation of virus perturbations through the PPI network at a significant rate. By following the main subdiffusive routes across the PPI network we identify proteins mainly expressed in the heart, cerebral cortex, thymus, testis, lymph node, kidney, among others of the organs reported to be affected by COVID-19.Competing Interest StatementThe authors have declared no competing interest.