RT Journal Article
SR Electronic
T1 Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPs
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.05.20.105809
DO 10.1101/2020.05.20.105809
A1 Román-Hurtado, Fernando
A1 Sánchez-Hidalgo, Marina
A1 Martín, Jesús
A1 Ortíz-López, Francisco Javier
A1 Genilloud, Olga
YR 2020
UL http://biorxiv.org/content/early/2020/05/22/2020.05.20.105809.abstract
AB Cacaoidin is the first member of the new lanthidin RiPP family, a lanthipeptide produced by the strain Streptomyces cacaoi CA-170360 with unprecedented features such as an unusually high number of D-amino acids, a double methylation in the N-terminal alanine and a tyrosine residue glycosylated with a disaccharide. In this work, we describe the complete identification, cloning and heterologous expression of the cacaoidin biosynthetic gene cluster, which shows unique RiPP genes.Competing Interest StatementThe authors have declared no competing interest.