RT Journal Article
SR Electronic
T1 Intrinsic defects in lymph node stromal cells underpin poor germinal center responses during aging
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.05.07.082255
DO 10.1101/2020.05.07.082255
A1 Alice E Denton
A1 Alyssa Silva-Cayetano
A1 James Dooley
A1 Danika L Hill
A1 Edward J Carr
A1 Philippe A Robert
A1 Michael Meyer-Hermann
A1 Adrian Liston
A1 Michelle A Linterman
YR 2020
UL http://biorxiv.org/content/early/2020/05/23/2020.05.07.082255.abstract
AB The failure to generate enduring humoral immunity after vaccination is a hallmark of advancing age. This can be attributed to a reduction in the germinal center response, which generates long-lived antibody-secreting cells that provide protection against (re)infection. Despite intensive investigation into the effect of age on the lymphoid compartment, the primary cellular defect that causes impaired germinal centers in aging has not been identified. Herein we demonstrate that aging reduces the capacity of germinal center-associated stromal cells to respond to vaccination. Heterochronic parabiosis and mathematical modeling demonstrate that a poor stromal cell response limits the size of the germinal center. This study reveals that age-associated defects in stromal cells are a significant barrier to efficacious vaccine responses in older individuals.Competing Interest StatementThe authors have declared no competing interest.