TY - JOUR T1 - Ultra-high field (10.5 T) resting state fMRI in the macaque JF - bioRxiv DO - 10.1101/2020.05.21.109595 SP - 2020.05.21.109595 AU - Essa Yacoub AU - Mark D. Grier AU - Edward J. Auerbach AU - Russell L. Lagore AU - Noam Harel AU - Kamil Ugurbil AU - Gregor Adriany AU - Anna Zilverstand AU - Benjamin Y. Hayden AU - Sarah R. Heilbronner AU - Jan Zimmermann Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/05/23/2020.05.21.109595.abstract N2 - Resting state functional connectivity refers to the temporal correlations between spontaneous hemodynamic signals obtained using functional magnetic resonance imaging. This technique has demonstrated that the structure and dynamics of identifiable networks are altered in psychiatric and neurological disease states. Thus, resting state network organizations can be used as a diagnostic, or prognostic recovery indicator. However, much about the physiological basis of this technique is unknown. Thus, providing a translational bridge to an optimal animal model, the macaque, in which invasive circuit manipulations are possible, is of utmost importance. Current approaches to resting state measurements in macaques face unique challenges associated with signal-to-noise, the need for invasive contrast agents, and within-subject designs. These limitations can, in principle, be overcome through ultra-high magnetic fields. However, ultra-high field imaging has yet to be adapted for fMRI in macaques. Here, we demonstrate that the combination of high channel count transmitter and receiver arrays, optimized pulse sequences, and careful anesthesia regimens, allows for detailed within-subject resting state analysis at ultra-high resolutions. In this study, we uncover thirty spatially detailed resting state components that are highly robust across individual macaques and closely resemble the quality and findings of connectomes from large human datasets. This detailed map of the rsfMRI ‘macaque connectome’ will be the basis for future neurobiological circuit manipulation work, providing valuable biological insights into human connectomics.Competing Interest StatementThe authors have declared no competing interest. ER -