RT Journal Article
SR Electronic
T1 Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.05.20.106401
DO 10.1101/2020.05.20.106401
A1 Divij Mathew
A1 Josephine R. Giles
A1 Amy E. Baxter
A1 Allison R. Greenplate
A1 Jennifer E. Wu
A1 Cécile Alanio
A1 Derek A. Oldridge
A1 Leticia Kuri-Cervantes
A1 M. Betina Pampena
A1 Kurt D’Andrea
A1 Sasikanth Manne
A1 Zeyu Chen
A1 Yinghui Jane Huang
A1 John P. Reilly
A1 Ariel R Weisman
A1 Caroline A.G. Ittner
A1 Oliva Kuthuru
A1 Jeanette Dougherty
A1 Kito Nzingha
A1 Nicholas Han
A1 Justin Kim
A1 Ajinkya Pattekar
A1 Eileen C. Goodwin
A1 Elizabeth M. Anderson
A1 Madison E. Weirick
A1 Sigrid Gouma
A1 Claudia P. Arevalo
A1 Marcus J. Bolton
A1 Fang Chen
A1 Simon F. Lacey
A1 Scott E. Hensley
A1 Sokratis Apostolidis
A1 Alexander C. Huang
A1 Laura A. Vella
A1 The UPenn COVID Processing Unit
A1 Michael R. Betts
A1 Nuala J. Meyer
A1 E. John Wherry
YR 2020
UL http://biorxiv.org/content/early/2020/05/23/2020.05.20.106401.abstract
AB COVID-19 has become a global pandemic. Immune dysregulation has been implicated, but immune responses remain poorly understood. We analyzed 71 COVID-19 patients compared to recovered and healthy subjects using high dimensional cytometry. Integrated analysis of ∼200 immune and >30 clinical features revealed activation of T cell and B cell subsets, but only in some patients. A subgroup of patients had T cell activation characteristic of acute viral infection and plasmablast responses could reach >30% of circulating B cells. However, another subgroup had lymphocyte activation comparable to uninfected subjects. Stable versus dynamic immunological signatures were identified and linked to trajectories of disease severity change. These analyses identified three “immunotypes” associated with poor clinical trajectories versus improving health. These immunotypes may have implications for therapeutics and vaccines.Competing Interest StatementThe authors have declared no competing interest.