PT  - JOURNAL ARTICLE
AU  - Hebing Chen
AU  - Zhuo Zhang
AU  - Shuai Jiang
AU  - Ruijiang Li
AU  - Wanying Li
AU  - Chenghui Zhao
AU  - Hao Hong
AU  - Xin Huang
AU  - Hao Li
AU  - Xiaochen Bo
TI  - New insights on human essential genes based on integrated analysis
AID  - 10.1101/260224
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 260224
4099  - http://biorxiv.org/content/early/2018/10/10/260224.short
4100  - http://biorxiv.org/content/early/2018/10/10/260224.full
AB  - Essential genes are those whose functions govern critical processes that sustain life in the organism. Recent gene-editing technologies have provided new opportunities to characterize essential genes. Here, we present an integrated analysis for comprehensively and systematically elucidating the genetic and regulatory characteristics of human essential genes. First, essential genes act as “hubs” in protein-protein interactions networks, in chromatin structure, and in epigenetic modifications, thus are essential for cell growth. Second, essential genes represent the conserved biological processes across species although gene essentiality changes itself. Third, essential genes are import for cell development due to its discriminate transcription activity in both embryo development and oncogenesis. In addition, we develop an interactive web server, the Human Essential Genes Interactive Analysis Platform (HEGIAP) (http://sysomics.com/HEGIAP/), which integrates abundant analytical tools to give a global, multidimensional interpretation of gene essentiality. Our study provides a new view for understanding human essential genes.