PT  - JOURNAL ARTICLE
AU  - Andre Altmann
AU  - Janaina Mourao-Miranda
TI  - Evidence for Bias of Genetic Ancestry in Resting State Functional MRI
AID  - 10.1101/440776
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 440776
4099  - http://biorxiv.org/content/early/2018/10/11/440776.short
4100  - http://biorxiv.org/content/early/2018/10/11/440776.full
AB  - Resting state functional magnetic resonance imaging (rs-fMRI) is a popular imaging modality for mapping the functional connectivity of the brain. Rs-fMRI is, just like other neuroimaging modalities, subject to a series of technical and subject level biases that change the inferred connectivity pattern. In this work we predicted genetic ancestry from rs-fMRI connectivity data at very high performance (area under the ROC curve of 0.93). Thereby, we demonstrated that genetic ancestry is encoded in the functional connectivity pattern of the brain at rest. Consequently, genetic ancestry constitutes a bias that should be accounted for in the analysis of rs-fMRI data.