RT Journal Article
SR Electronic
T1 Evidence for Bias of Genetic Ancestry in Resting State Functional MRI
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 440776
DO 10.1101/440776
A1 Andre Altmann
A1 Janaina Mourao-Miranda
YR 2018
UL http://biorxiv.org/content/early/2018/10/11/440776.abstract
AB Resting state functional magnetic resonance imaging (rs-fMRI) is a popular imaging modality for mapping the functional connectivity of the brain. Rs-fMRI is, just like other neuroimaging modalities, subject to a series of technical and subject level biases that change the inferred connectivity pattern. In this work we predicted genetic ancestry from rs-fMRI connectivity data at very high performance (area under the ROC curve of 0.93). Thereby, we demonstrated that genetic ancestry is encoded in the functional connectivity pattern of the brain at rest. Consequently, genetic ancestry constitutes a bias that should be accounted for in the analysis of rs-fMRI data.