RT Journal Article
SR Electronic
T1 Mapping social reward and punishment processing in the human brain: A voxel-based meta-analysis of neuroimaging findings using the Social Incentive Delay task
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.05.28.121475
DO 10.1101/2020.05.28.121475
A1 D. Martins
A1 L. Rademacher
A1 A. S. Gabay
A1 R. Taylor
A1 J. A. Richey
A1 D. Smith
A1 K. S. Goerlich
A1 L. Nawijn
A1 H.R. Cremers
A1 R. Wilson
A1 S. Bhattacharyya
A1 Y. Paloyelis
YR 2020
UL http://biorxiv.org/content/early/2020/05/30/2020.05.28.121475.abstract
AB Social incentives (rewards or punishments) motivate human learning and behaviour, and alterations in the brain circuits involved in the processing social incentives have been linked with several neuropsychiatric disorders. However, questions still remain about the exact neural substrates implicated in social incentive processing. Here, we conducted four Anisotropic Effect Size Signed Differential Mapping voxel-based meta-analyses of fMRI studies investigating the neural correlates of the anticipation and receipt of social rewards and punishments using the Social Incentive Delay task. We map the regions involved in each of these four processes in the human brain, identify decreases in the BOLD signal during the anticipation of both social reward and punishment avoidance that were missed in individual studies due to a lack of power, and characterise the effect size and direction of changes in the BOLD signal for each brain area. Our results provide a better understanding of the brain circuitry involved in social incentive processing and can inform hypotheses about potentially disrupted brain areas linked with dysfunctional social incentive processing during disease.Voxel-based meta-analysis of the neural underpinnings of social incentive processingWe map the brain regions involved in the processing of social incentives in humansWe identify new regions missed in individual studies as a result of lack of powerOur work can inform research on pathological brain processing of social incentivesCompeting Interest StatementThe authors have declared no competing interest.