%0 Journal Article %A Lars Hunger %A Arvind Kumar %A Robert Schmidt %T Abundance compensates kinetics: Similar effect of dopamine signals on D1 and D2 receptor populations %D 2018 %R 10.1101/444984 %J bioRxiv %P 444984 %X The properties of different dopamine receptors constrain the function of dopamine signals in the striatum of the basal ganglia. Still, dopamine receptor kinetics are often neglected in considerations of the temporal dynamics of dopamine signalling. Here we develop a neurochemical model of dopamine receptor binding taking into account slow receptor kinetics. Contrary to current views, in our model D1 and D2 dopamine receptor populations react very similarly to dopamine signals independent of their timescale and integrate them over minutes. Furthermore, our model explains why ramping dopamine concentrations, observed experimentally, are an effective signal for increasing the occupancy of dopamine receptors. %U https://www.biorxiv.org/content/biorxiv/early/2018/10/16/444984.full.pdf