PT  - JOURNAL ARTICLE
AU  - Frederike Winkel
AU  - Mathias B. Voigt
AU  - Giuliano Didio
AU  - Salomé Matéo
AU  - Elias Jetsonen
AU  - Maria Llach Pou
AU  - Anna Steinzeig
AU  - Maria Ryazantseva
AU  - Juliana Harkki
AU  - Jonas Englund
AU  - Stanislav Khirug
AU  - Claudio Rivera
AU  - Satu Palva
AU  - Tomi Taira
AU  - Sari E. Lauri
AU  - Juzoh Umemori
AU  - Eero Castrén
TI  - Optical TrkB activation in Parvalbumin interneurons regulates intrinsic states to orchestrate cortical plasticity
AID  - 10.1101/2020.04.27.063503
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.04.27.063503
4099  - http://biorxiv.org/content/early/2020/06/04/2020.04.27.063503.short
4100  - http://biorxiv.org/content/early/2020/06/04/2020.04.27.063503.full
AB  - Activation state of Parvalbumin (PV) interneurons regulates neuronal plasticity, driving the closure of developmental critical periods and alternating between high and low plasticity states in response to experience in adulthood. We now show that PV plasticity states are regulated through the activation of TrkB neurotrophin receptors. Activation of an optically activatable TrkB (optoTrkB) specifically in PV interneurons switches adult cortical networks into a state of elevated plasticity within minutes by decreasing excitability of PV neurons. OptoTrkB activation induces changes in gene expression related to neuronal plasticity and excitability, and increases the phosphorylation of Kv3.1 channels. OptoTrkB activation shifted cortical networks towards a low PV configuration, promoting oscillatory synchrony and ocular dominance plasticity. Visual plasticity induced by fluoxetine was lost in mice lacking TrkB in PV neurons. Our data suggest a novel mechanism that dynamically regulates PV interneurons configuration state and orchestrates cortical networks during adulthood.Competing Interest StatementEC has received a lecturer fee from Jansen Cilac.