RT Journal Article
SR Electronic
T1 The coupling of global brain activity and cerebrospinal fluid inflow is correlated with Alzheimer’s disease related pathology
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.04.134726
DO 10.1101/2020.06.04.134726
A1 Feng Han
A1 Jing Chen
A1 Aaron Belkin-Rosen
A1 Yameng Gu
A1 Liying Luo
A1 Orfeu M. Buxton
A1 Xiao Liu
A1 Alzheimer’s Disease Neuroimaging Initiative
YR 2020
UL http://biorxiv.org/content/early/2020/06/05/2020.06.04.134726.abstract
AB The glymphatic system plays an important role in clearing the amyloid-β and tau proteins that are closely linked to Alzheimer’s disease (AD) pathology. Glymphatic clearance, as well as amyloid-β accumulation, is highly dependent on sleep, but the sleep-dependent driving forces behind cerebrospinal fluid (CSF) movements essential to the glymphatic flux remain largely unclear. Recent studies have reported that widespread, high-amplitude spontaneous brain activations in the drowsy state and during sleep, which are shown as large global signal peaks in resting-state fMRI, is coupled with the CSF movements, suggesting their potential link to the glymphatic flux and metabolite clearance. By analyzing multimodal data from the Alzheimer’s Disease Neuroimaging Initiative project, here we showed that the coupling between the global fMRI signal and CSF influx is correlated with AD-related pathology, including various risk factors for AD, the severity of AD-related diseases, the cortical amyloid-β level, and the cognitive decline over a two-year follow-up. These results provide critical initial evidence for involvement of sleep-dependent global brain activity, as well as the associated physiological modulations, in the clearance of AD-related brain waste.Competing Interest StatementThe authors have declared no competing interest.