RT Journal Article
SR Electronic
T1 Cortical activity at different time scales: high-pass filtering separates motor planning and execution
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 857300
DO 10.1101/857300
A1 David Eriksson
A1 Mona Heiland
A1 Artur Schneider
A1 Ilka Diester
YR 2020
UL http://biorxiv.org/content/early/2020/06/06/857300.abstract
AB The smooth conduction of movements requires simultaneous motor planning and execution according to internal goals. So far it is not known how such movement plans can be modified without being distorted by ongoing movements. Previous studies have isolated planning and execution related neuronal activity by separating behavioral planning and movement periods in time by sensory cues1–7. Here, we introduced two novel tasks in which motor planning developed intrinsically. We separated this continuous self-paced motor planning statistically from motor execution by experimentally minimizing the repetitiveness of the movements. Thereby, we found that in the rat sensorimotor cortex, neuronal motor planning processes evolved with slower dynamics than movement related responses both on a sorted unit and population level. The fast evolving neuronal activity preceded skilled forelimb movements while it coincided with movements in a locomotor task. We captured this fast evolving movement related activity via a high-pass filter approach and confirmed the results with optogenetic stimulations. As biological mechanism underlying such a high pass filtering we suggest neuronal adaption. The differences in dynamics combined with a high pass filtering mechanism represents a simple principle for concurrent motor planning and execution in which planning will result in relatively slow dynamics that will not produce movements.Competing Interest StatementThe authors have declared no competing interest.