RT Journal Article
SR Electronic
T1 Choice suppression is achieved through opponent but not independent function of the striatal indirect pathway in mice
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 675850
DO 10.1101/675850
A1 Delevich, Kristen
A1 Hoshal, Benjamin
A1 Collins, Anne GE
A1 Wilbrecht, Linda
YR 2020
UL http://biorxiv.org/content/early/2020/06/06/675850.abstract
AB The dorsomedial striatum (DMS) plays a key role in action selection, but little is known about how direct and indirect pathway spiny projection neurons (dSPNs and iSPNs) contribute to choice suppression in freely moving animals. Here, we used pathway-specific chemogenetic manipulation during a serial choice foraging task to test opposing predictions for iSPN function generated by two theories: 1) the ‘select/suppress’ heuristic which suggests iSPN activity is required to suppress alternate choices and 2) the network-inspired Opponent Actor Learning model (OpAL) which proposes that the weighted difference of dSPN and iSPN activity determines choice. We found that chemogenetic activation, but not inhibition, of iSPNs disrupted learned suppression of nonrewarded choices, consistent with the predictions of the OpAL model. Our findings suggest that iSPNs’ role in stopping and freezing does not extend in a simple fashion to choice suppression. These data may provide insights critical for the successful design of interventions for addiction or other conditions in which suppression of behavior is desirable.Competing Interest StatementThe authors have declared no competing interest.