PT  - JOURNAL ARTICLE
AU  - Anna C. Schapiro
AU  - Allison G. Reid
AU  - Alexandra Morgan
AU  - Dara S. Manoach
AU  - Mieke Verfaellie
AU  - Robert Stickgold
TI  - The hippocampus is necessary for the sleep-dependent consolidation of a task that does not require the hippocampus for initial learning
AID  - 10.1101/451195
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 451195
4099  - http://biorxiv.org/content/early/2018/10/23/451195.short
4100  - http://biorxiv.org/content/early/2018/10/23/451195.full
AB  - During sleep, the hippocampus plays an active role in consolidating memories that depend on it for initial encoding. There are hints in the literature that the hippocampus may have a broader influence, contributing to the consolidation of memories that may not initially require the area. We tested this possibility by evaluating learning and consolidation of the motor sequence task (MST) in hippocampal amnesics and demographically matched control participants. While the groups showed similar initial learning, only controls exhibited evidence of sleep-dependent consolidation. These results demonstrate that the hippocampus can be required for normal consolidation of a task without being required for its acquisition, suggesting that the area plays a broader role in coordinating sleep-dependent memory consolidation than has previously been assumed.