RT Journal Article
SR Electronic
T1 The hippocampus is necessary for the sleep-dependent consolidation of a task that does not require the hippocampus for initial learning
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 451195
DO 10.1101/451195
A1 Schapiro, Anna C.
A1 Reid, Allison G.
A1 Morgan, Alexandra
A1 Manoach, Dara S.
A1 Verfaellie, Mieke
A1 Stickgold, Robert
YR 2018
UL http://biorxiv.org/content/early/2018/10/23/451195.abstract
AB During sleep, the hippocampus plays an active role in consolidating memories that depend on it for initial encoding. There are hints in the literature that the hippocampus may have a broader influence, contributing to the consolidation of memories that may not initially require the area. We tested this possibility by evaluating learning and consolidation of the motor sequence task (MST) in hippocampal amnesics and demographically matched control participants. While the groups showed similar initial learning, only controls exhibited evidence of sleep-dependent consolidation. These results demonstrate that the hippocampus can be required for normal consolidation of a task without being required for its acquisition, suggesting that the area plays a broader role in coordinating sleep-dependent memory consolidation than has previously been assumed.