RT Journal Article
SR Electronic
T1 Cytokine and Leukocyte Profiling Reveal Pro-Inflammatory and Autoimmune Features in Frontotemporal Dementia Patients
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 049791
DO 10.1101/049791
A1 Philipp A. Jaeger
A1 Trisha M. Stan
A1 Eva Czirr
A1 Markus Britschgi
A1 Daniela Berdnik
A1 Ruo-Pan Huang
A1 Bradley F. Boeve
A1 Adam L. Boxer
A1 NiCole Finch
A1 Gabriela K. Fragiadakis
A1 Neill R. Graff-Radford
A1 Ruochun Huang
A1 Hudson Johns
A1 Anna Karydas
A1 David S. Knopman
A1 Michael Leipold
A1 Holden Maecker
A1 Zachary Miller
A1 Ronald C. Petersen
A1 Rosa Rademakers
A1 Chung-Huan Sun
A1 Steve Younkin
A1 Bruce L. Miller
A1 Tony Wyss-Coray
YR 2016
UL http://biorxiv.org/content/early/2016/04/22/049791.abstract
AB The growing link between systemic environment and brain function opens the possibility that cellular communication and composition in blood are correlated with brain health. We tested this concept in frontotemporal dementia with novel, unbiased tools that measure hundreds of soluble signaling proteins or characterize the vast immune cell repertoire in blood. With these tools we discovered complementary abnormalities indicative of abnormal T cell populations and autoimmunity in frontotemporal dementia.