RT Journal Article
SR Electronic
T1 An integrative study of five biological clocks in somatic and mental health
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.11.146498
DO 10.1101/2020.06.11.146498
A1 Jansen, Rick
A1 Verhoeven, Josine
A1 Han, Laura KM
A1 Aberg, Karolina A
A1 van den Oord, Edwin CGJ
A1 Milaneschi, Yuri
A1 Penninx, Brenda WJH
YR 2020
UL http://biorxiv.org/content/early/2020/06/12/2020.06.11.146498.abstract
AB Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illnesses and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether 5 biological clocks (telomere length, epigenetic, transcriptomic, proteomic and metabolomic clocks) were interrelated and associated to somatic and mental health determinants. Correlations between biological clocks were small (all r<0.2), indicating little overlap. The most consistent associations with the advanced biological clocks were found for male sex, higher BMI, metabolic syndrome, smoking and depression. As compared to the individual clocks, a composite index of all five clocks showed most pronounced associations with health determinants. The large effect sizes of the composite index and the low correlation between biological clocks, indicate that one’s biological age is best reflected by combining aging measures from multiple cellular levels.