PT  - JOURNAL ARTICLE
AU  - Chayut Teeraratkul
AU  - Zachariah Irwin
AU  - Shawn C. Shadden
AU  - Debanjan Mukherjee
TI  - Computational Investigation Of Blood Flow And Flow-mediated Transport In Arterial Thrombus Neighborhood
AID  - 10.1101/2020.06.11.147488
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.06.11.147488
4099  - http://biorxiv.org/content/early/2020/06/12/2020.06.11.147488.short
4100  - http://biorxiv.org/content/early/2020/06/12/2020.06.11.147488.full
AB  - A pathologically formed blood clot or thrombus is central to major cardiovascular diseases like heart attack and stroke. Detailed quantitative evaluation of flow and flow-mediated transport processes in the thrombus neighborhood within large artery hemodynamics is crucial for understanding disease progression and assessing treatment efficacy. This, however, remains a challenging task owing to the complexity of pulsatile viscous flow interactions with arbitrary shape and heterogeneous microstructure of realistic thrombi. Here, we address this challenge by conducting a systematic parametric simulation based study on characterizing unsteady hemodynamics and flow-mediated transport in the neighborhood of an arterial thrombus. We use a hybrid particle-continuum based finite element approach to handle arbitrary thrombus shape and microstructural variations. Results from a cohort of 50 different unsteady flow scenarios are presented, including unsteady vortical structures, pressure-gradient across the thrombus boundary, finite time Lyapunov exponents, and dynamic coherent structures that organize advective transport. We clearly illustrate the synergistic influence of three key parameters - thrombus shape, microstructure, and extent of wall disease - in terms of: (a) determining hemodynamic features in the thrombus neighborhood; and (b) governing the balance between advection, permeation, and diffusion to regulate transport processes in the thrombus neighborhood.Competing Interest StatementThe authors have declared no competing interest.