RT Journal Article
SR Electronic
T1 Extending FreeSurfer to estimate sulcal morphology
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 452789
DO 10.1101/452789
A1 Christopher R. Madan
YR 2018
UL http://biorxiv.org/content/early/2018/10/25/452789.abstract
AB While it is well established that cortical morphology differs in relation to a variety of inter-individual factors, it is often characterized using estimates of volume, thickness, surface area, or gyrification. Here I developed a computational approach for estimating sulcal width and depth that relies on cortical surface reconstructions output by FreeSurfer. While other approaches for estimating sulcal morphology exist, studies often are require the use of multiple brain morphology programs that have been shown to differ in their approaches to localize sulcal landmarks, yielding morphological estimates based on inconsistent boundaries. To demonstrate the approach, sulcal morphology was estimated in three large sample of adults across the lifespan, in relation to aging. A fourth sample is additionally used to estimate test-retest reliability of the approach. This toolbox is now made freely available as supplemental to this paper: https://cmadan.github.io/calcSulc/.