RT Journal Article
SR Electronic
T1 Adaptation of bacteria to glyphosate: a microevolutionary perspective of the enzyme 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.16.154005
DO 10.1101/2020.06.16.154005
A1 Miia J. Rainio
A1 Suvi Ruuskanen
A1 Marjo Helander
A1 Kari Saikkonen
A1 Irma Saloniemi
A1 Pere Puigbò
YR 2020
UL http://biorxiv.org/content/early/2020/06/16/2020.06.16.154005.abstract
AB Glyphosate is the leading herbicide worldwide, but it also affects prokaryotes because it targets the central enzyme (EPSPS) of the shikimate pathway in the synthesis of the three essential aromatic amino acids in autotrophs. Our results reveal that bacteria easily become resistant to glyphosate through changes in the EPSPS active site. This indicates the importance of examining how glyphosate affects microbe-mediated ecosystem functions and human microbiomes.Competing Interest StatementThe authors have declared no competing interest.