RT Journal Article
SR Electronic
T1 Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.17.155044
DO 10.1101/2020.06.17.155044
A1 Giulio E. Brancati
A1 Chahinaz Rawas
A1 Antoine Ghestem
A1 Christophe Bernard
A1 Anton I. Ivanov
YR 2020
UL http://biorxiv.org/content/early/2020/06/17/2020.06.17.155044.abstract
AB Energy production, mostly via glycolysis and oxidative phosphorylation, which is at the core of cell function, varies in a circadian manner. Whether energy production is tailored to the functional needs of the networks remains poorly understood. The dorsal and ventral part of the hippocampus are involved in different functional circuits. Using metabolic imaging and metabolite sensing, we show that the ventral hippocampus favors aerobic glycolysis over oxidative phosphorylation as compared to the dorsal part in the morning. However, in the afternoon, aerobic glycolysis is decreased and oxidative phosphorylation increased in the ventral hippocampus. In the dorsal hippocampus, the metabolic activity varies less between these two times but is still weaker than in the ventral. Thus, energy metabolism is different in space (along the dorso-ventral axis) and time (in a circadian manner) in the hippocampus. A similar analysis in an experimental model of epilepsy revealed a large alteration of such spatio-temporal organization. In addition to a general hypometabolic state, the spatial difference disappeared in the morning, when seizure probability is low. In the afternoon, when seizure probability is high, the aerobic glycolysis was enhanced in both parts but this increase was stronger in the ventral area. We suggest that energy metabolism is tailored to the functions performed by brain networks, which vary in space and time. In pathological conditions, the alterations of these general rules may contribute to network dysfunctions.Competing Interest StatementThe authors have declared no competing interest.