PT  - JOURNAL ARTICLE
AU  - Pingtao Ding
AU  - Toshiyuki Sakai
AU  - Ram Krishna Shrestha
AU  - Nicolas Manosalva Perez
AU  - Wenbin Guo
AU  - Bruno Pok Man Ngou
AU  - Shengbo He
AU  - Chang Liu
AU  - Xiaoqi Feng
AU  - Runxuan Zhang
AU  - Klaas Vandepoele
AU  - Dan MacLean
AU  - Jonathan DG Jones
TI  - Chromatin accessibility landscapes activated by cell surface and intracellular immune receptors
AID  - 10.1101/2020.06.17.157040
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.06.17.157040
4099  - http://biorxiv.org/content/early/2020/06/18/2020.06.17.157040.short
4100  - http://biorxiv.org/content/early/2020/06/18/2020.06.17.157040.full
AB  - Activation of cell Surface and Intracellular Receptor-Mediated Immunity (SRMI and IRMI) results in rapid transcriptional reprogramming that underpins disease resistance. However, the mechanisms by which SRMI and IRMI lead to transcriptional changes are not clear. Here, we combine RNA-seq and ATAC-seq to define changes in gene expression and chromatin accessibility; both SRMI and IRMI increase chromatin accessibility at induced defense genes. Analysis of ATAC-seq and RNA-seq data combined with publicly available information on transcription factor DNA-binding motifs enabled comparison of individual gene regulatory networks activated by SRMI and IRMI, and by both. These results and analyses reveal overlapping and conserved transcriptional regulatory mechanism between the two immune systems.Competing Interest StatementThe authors have declared no competing interest.