RT Journal Article SR Electronic T1 Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders JF bioRxiv FD Cold Spring Harbor Laboratory SP 453332 DO 10.1101/453332 A1 Evangelos Evangelou A1 He Gao A1 Congying Chu A1 Georgios Ntritsos A1 Paul Blakeley A1 Andrew R. Butts A1 Raha Pazoki A1 Hideaki Suzuki A1 Fotios Koskeridis A1 Andrianos M. Yiorkas A1 Ibrahim Karaman A1 Joshua Elliott A1 Stefanie Aeschbacher A1 Traci M. Bartz A1 Sebastian E. Baumeister A1 Peter S. Braund A1 Michael R. Brown A1 Jennifer A. Brody A1 Toni-Kim Clarke A1 Niki Dimou A1 Jessica D. Faul A1 Georg Homuth A1 Anne U. Jackson A1 Katherine A. Kentistou A1 Peter K. Joshi A1 Rozenn N. Lemaitre A1 Penelope A. Lind A1 Leo-Pekka Lyytikäinen A1 Massimo Mangino A1 Yuri Milaneschi A1 Christopher P. Nelson A1 Ilja M. Nolte A1 Mia-Maria Perälä A1 Ozren Polasek A1 David Porteous A1 Scott M. Ratliff A1 Jennifer A. Smith A1 Alena Stančáková A1 Alexander Teumer A1 Samuli Tuominen A1 Sébastien Thériault A1 Jagadish Vangipurapu A1 John B. Whitfield A1 Alexis Wood A1 Jie Yao A1 Bing Yu A1 Wei Zhao A1 Dan E. Arking A1 Juha Auvinen A1 Chunyu Liu A1 Minna Männikkö A1 Lorenz Risch A1 Jerome I. Rotter A1 Harold Snieder A1 Juha Veijola A1 Alexandra I. Blakemore A1 Michael Boehnke A1 Harry Campbell A1 David Conen A1 Johan G. Eriksson A1 Hans J. Grabe A1 Xiuqing Guo A1 Pim van der Harst A1 Catharina A. Hartman A1 Caroline Hayward A1 Andrew C. Heath A1 Marjo-Riitta Jarvelin A1 Mika Kähönen A1 Sharon LR Kardia A1 Michael Kühne A1 Johanna Kuusisto A1 Markku Laakso A1 Jari Lahti A1 Terho Lehtimäki A1 Andrew M. McIntosh A1 Karen L. Mohlke A1 Alanna C. Morrison A1 Nicholas G. Martin A1 Albertine J. Oldehinkel A1 Brenda WJH Penninx A1 Bruce M. Psaty A1 Olli T. Raitakari A1 Igor Rudan A1 Nilesh J. Samani A1 Laura J. Scott A1 Tim D. Spector A1 Niek Verweij A1 David R. Weir A1 James F. Wilson A1 Daniel Levy A1 Ioanna Tzoulaki A1 Jimmy D. Bell A1 Paul Matthews A1 Adrian Rothenfluh A1 Sylvane Desrivières A1 Gunter Schumann A1 Paul Elliott YR 2018 UL http://biorxiv.org/content/early/2018/10/30/453332.abstract AB Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a genome-wide association study (GWAS) of alcohol use in ~480,000 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigated their potential functional significance using magnetic resonance imaging data, gene expression and behavioral studies in Drosophila. Our results identify new genetic pathways associated with alcohol consumption and suggest common genetic mechanisms with several neuropsychiatric disorders including schizophrenia.