RT Journal Article
SR Electronic
T1 Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.20.159715
DO 10.1101/2020.06.20.159715
A1 Simon P. Graham
A1 Rebecca K. McLean
A1 Alexandra J. Spencer
A1 Sandra Belij-Rammerstorfer
A1 Daniel Wright
A1 Marta Ulaszewska
A1 Jane C. Edwards
A1 Jack W. P. Hayes
A1 Veronica Martini
A1 Nazia Thakur
A1 Carina Conceicao
A1 Isabelle Dietrich
A1 Holly Shelton
A1 Ryan Waters
A1 Anna Ludi
A1 Ginette Wilsden
A1 Clare Browning
A1 Dagmara Bialy
A1 Sushant Bhat
A1 Phoebe Stevenson-Leggett
A1 Philippa Hollinghurst
A1 Ciaran Gilbride
A1 David Pulido
A1 Katy Moffat
A1 Hannah Sharpe
A1 Elizabeth Allen
A1 Valerie Mioulet
A1 Chris Chiu
A1 Joseph Newman
A1 Amin S. Asfor
A1 Alison Burman
A1 Sylvia Crossley
A1 Jiandong Huo
A1 Raymond J. Owens
A1 Miles Carroll
A1 John A. Hammond
A1 Elma Tchilian
A1 Dalan Bailey
A1 Bryan Charleston
A1 Sarah C. Gilbert
A1 Tobias J. Tuthill
A1 Teresa Lambe
YR 2020
UL http://biorxiv.org/content/early/2020/06/20/2020.06.20.159715.abstract
AB Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres.Competing Interest StatementSarah Gilbert and Teresa Lambe are named on a patent application covering ChAdOx1 nCoV-19. The remaining authors declare no competing interests. The funders played no role in the conceptualisation, design, data collection, analysis, the decision to publish, or preparation of the manuscript.