PT  - JOURNAL ARTICLE
AU  - Leek, Jeffrey T.
AU  - Jager, Leah R.
TI  - Is most published research really false?
AID  - 10.1101/050575
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 050575
4099  - http://biorxiv.org/content/early/2016/04/27/050575.short
4100  - http://biorxiv.org/content/early/2016/04/27/050575.full
AB  - There has been an increasing concern that most published medical findings are false. But what does it mean to be false? Here we describe the range of definitions of false discoveries in the scientific literature. We summarize the philosophical, statistical, and experimental evidence for each type of false discovery. We discuss common underpinning problems with the scientific and data analytic practices and point to tools and behaviors that can be implemented to reduce the problems with published scientific results.