RT Journal Article
SR Electronic
T1 Age-dependent glycomic response to the 2009 pandemic H1N1 influenza virus and its association with disease severity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.22.165613
DO 10.1101/2020.06.22.165613
A1 Shuhui Chen
A1 Brian Kasper
A1 Bin Zhang
A1 Lauren P. Lashua
A1 Ted M. Ross
A1 Elodie Ghedin
A1 Lara K. Mahal
YR 2020
UL http://biorxiv.org/content/early/2020/06/22/2020.06.22.165613.abstract
AB Influenza A viruses cause a spectrum of responses, from mild cold-like symptoms to severe respiratory illness and death. Viral strains and intrinsic host factors, such as age, can influence the severity of the disease. Glycosylation plays a critical role in influenza pathogenesis, however the molecular drivers of influenza outcomes remain unknown. In this work, we characterized the glycomic response to the H1N1 2009 pandemic influenza A virus in age-dependent severity. Using a ferret model and a lectin microarray technology we have developed, we compared responses in newly weaned and aged animals, a model for young children and the elderly, respectively. Glycomic analysis revealed changes in glycosylation over the course of the infection, that were associated with severity in an age-dependent manner. These responses may help explain the differential susceptibility to influenza A virus infection of young children and the elderly.Competing Interest StatementThe authors have declared no competing interest.