PT - JOURNAL ARTICLE AU - Luis J. Gomez AU - Moritz Dannhauer AU - Angel V. Peterchev TI - Fast computational optimization of TMS coil placement for individualized electric field targeting AID - 10.1101/2020.05.27.120022 DP - 2020 Jan 01 TA - bioRxiv PG - 2020.05.27.120022 4099 - http://biorxiv.org/content/early/2020/06/23/2020.05.27.120022.short 4100 - http://biorxiv.org/content/early/2020/06/23/2020.05.27.120022.full AB - Background During transcranial magnetic stimulation (TMS) a coil placed on the scalp is used to non-invasively modulate activity of targeted brain networks via a magnetically induced electric field (E-field). Ideally, the E-field induced during TMS is concentrated on a targeted cortical region of interest (ROI).Objective To improve the accuracy of TMS we have developed a fast computational auxiliary dipole method (ADM) for determining the optimum coil position and orientation. The optimum coil placement maximizes the E-field along a predetermined direction or, alternatively, the overall E-field magnitude in the targeted ROI. Furthermore, ADM can assess E-field uncertainty resulting from precision limitations of TMS coil placement protocols.Method ADM leverages the electromagnetic reciprocity principle to compute rapidly the TMS induced E-field in the ROI by using the E-field generated by a virtual constant current source residing in the ROI. The framework starts by solving for the conduction currents resulting from this ROI current source. Then, it rapidly determines the average E-field induced in the ROI for each coil position by using the conduction currents and a fast-multipole method. To further speed-up the computations, the coil is approximated using auxiliary dipoles enabling it to represent all coil orientations for a given coil position with less than 600 dipoles.Results Using ADM, the E-fields generated in an MRI-derived head model when the coil is placed at 5,900 different scalp positions and 360 coil orientations per position (over 2.1 million unique configurations) can be determined in under 15 minutes on a standard laptop computer. This enables rapid extraction of the optimum coil position and orientation as well as the E-field variation resulting from coil positioning uncertainty.Conclusion ADM enables the rapid determination of coil placement that maximizes E-field delivery to a specific brain target. This method can find the optimum coil placement in under 15 minutes enabling its routine use for TMS. Furthermore, it enables the fast quantification of uncertainty in the induced E-field due to limited precision of TMS coil placement protocols, enabling minimization and statistical analysis of the E-field dose variability.HighlightsAuxiliary dipole method (ADM) optimizes TMS coil placement in under 8 minutesOptimum coil position is up to 14 mm away from conventional targetingOptimum coil orientation is typically near normal to the sulcal wallTMS induced E-field is less sensitive to orientation than position errorsCompeting Interest StatementThe authors have declared no competing interest.