PT  - JOURNAL ARTICLE
AU  - Sandra K. Johnston
AU  - Paula Whitmire
AU  - Susan Christine Massey
AU  - Priya Kumthekar
AU  - Alyx B. Porter
AU  - Natarajan Raghunand
AU  - Luis F. Gonzalez-Cuyar
AU  - Maciej M. Mrugala
AU  - Andrea Hawkins-Daarud
AU  - Pamela R. Jackson
AU  - Leland S. Hu
AU  - Jann N. Sarkaria
AU  - Lei Wang
AU  - Robert A. Gatenby
AU  - Kathleen M. Egan
AU  - Peter Canoll
AU  - Kristin R. Swanson
AU  - on behalf of the ENDURES consortium
TI  - ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: a Multi-disciplinary Team-based, Multifactorial Analytical Approach
AID  - 10.1101/461236
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 461236
4099  - http://biorxiv.org/content/early/2018/11/04/461236.short
4100  - http://biorxiv.org/content/early/2018/11/04/461236.full
AB  - Although glioblastoma is a fatal primary brain cancer with a short median survival of 15 months, a small number of patients survive more than 5 years after diagnosis; they are known as extreme survivors (ES). Due to their rarity, very little is known about what differentiates these outliers from other glioblastoma patients. For the purpose of identifying unknown drivers of extreme survivorship in glioblastoma, we developed the ENDURES consortium (ENvironmental Dynamics Underlying Responsive Extreme Survivors of glioblastoma). This consortium is a multicenter collaborative network of investigators focused on the integration of multiple types of clinical data and the creation of patient-specific models of tumor growth informed by radiographic and histological parameters. Leveraging our combined resources, the goals of the ENDURES consortium are two-fold: (1) to build a curated, searchable, multilayered repository housing clinical and outcome data on a large cohort of ES patients with glioblastoma and (2) to leverage the ENDURES repository for new insights on tumor behavior and novel targets for prolonging survival for all glioblastoma patients. In this article, we review the available literature and discuss what is already known about ES. We then describe the creation of our consortium and some of our preliminary results.Funding This review was financially supported by a grant from the James S. McDonnell FoundationConflicts of Interest The authors have declared that no conflicts of interest exist.Authorship Conceptualized consortium: LW, RG, KME, PC, and KRS. Built consortium: SKJ, PK, NR, JS, KME, PC, and KRS. Wrote the manuscript: SKJ, PW, SCM, PK, AP, and KME. Reviewed and edited the manuscript: LFGC, MMM, AHD, PRJ, and LSH. Contributed to writing, provided feedback, and approved of final manuscript: All authors.Link to website for ENDURES http://mathematicalneurooncology.org/?page_id=2125