PT  - JOURNAL ARTICLE
AU  - J.M. Stujenske
AU  - P.K. O’Neill
AU  - I Nahmoud
AU  - S. Goldberg
AU  - L. Diaz
AU  - M. Labkovich
AU  - W. Hardin
AU  - S.S. Bolkan
AU  - T.R. Reardon
AU  - T.J. Spellman
AU  - C.D. Salzman
AU  - J.A. Gordon
AU  - E. Likhtik
TI  - Prelimbic-dependent activation of amygdala somatostatin interneurons signals non-aversive cues to promote discrimination
AID  - 10.1101/2020.06.23.156018
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.06.23.156018
4099  - http://biorxiv.org/content/early/2020/06/24/2020.06.23.156018.short
4100  - http://biorxiv.org/content/early/2020/06/24/2020.06.23.156018.full
AB  - The amygdala and prelimbic cortex (PL) communicate during fear discrimination retrieval, but how they coordinate to discriminate a non-threatening stimulus is unknown. Here, we show that somatostatin interneurons (SOM) in the basolateral amygdala (BLA) become active specifically during learned non-threatening cues, when they block sensory-evoked phase resetting of theta-oscillations. Further, we show that SOM activation is PL-dependent, and promotes discrimination of non-threat. Thus, fear discrimination engages PL-dependent coordination of BLA SOM responses to non-threatening stimuli.Competing Interest StatementThe authors have declared no competing interest.