RT Journal Article
SR Electronic
T1 Prelimbic-dependent activation of amygdala somatostatin interneurons signals non-aversive cues to promote discrimination
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.23.156018
DO 10.1101/2020.06.23.156018
A1 J.M. Stujenske
A1 P.K. O’Neill
A1 I Nahmoud
A1 S. Goldberg
A1 L. Diaz
A1 M. Labkovich
A1 W. Hardin
A1 S.S. Bolkan
A1 T.R. Reardon
A1 T.J. Spellman
A1 C.D. Salzman
A1 J.A. Gordon
A1 E. Likhtik
YR 2020
UL http://biorxiv.org/content/early/2020/06/24/2020.06.23.156018.abstract
AB The amygdala and prelimbic cortex (PL) communicate during fear discrimination retrieval, but how they coordinate to discriminate a non-threatening stimulus is unknown. Here, we show that somatostatin interneurons (SOM) in the basolateral amygdala (BLA) become active specifically during learned non-threatening cues, when they block sensory-evoked phase resetting of theta-oscillations. Further, we show that SOM activation is PL-dependent, and promotes discrimination of non-threat. Thus, fear discrimination engages PL-dependent coordination of BLA SOM responses to non-threatening stimuli.Competing Interest StatementThe authors have declared no competing interest.