TY - JOUR T1 - Quantifying Color Vision Changes Associated with Cataracts Using Cone Contrast Thresholds JF - bioRxiv DO - 10.1101/2020.06.27.175570 SP - 2020.06.27.175570 AU - Urmi Mehta AU - Anna Diep AU - Kevin Nguyen AU - Bryan Le AU - Clara Yuh AU - Caroline Frambach AU - John Doan AU - Ang Wei AU - Anton M. Palma AU - Marjan Farid AU - Sumit Garg AU - Sanjay Kedhar AU - Matthew Wade AU - Kailey A. Marshall AU - Kimberly A. Jameson AU - M. Cristina Kenney AU - Andrew W. Browne Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/06/28/2020.06.27.175570.abstract N2 - Purpose The cone contrast threshold (CCT) test quantified color vision changes in subjects of all ages and those undergoing cataract surgery.Methods Twenty-four healthy volunteers from two cohort studies performed CCT using best corrected visual acuity, filters, mydriasis, and pinhole correction. Retrospective cross-sectional study of patients seen in eye clinics evaluated the relationship between age and color vision, and age and lens status in 355 eyes. Lastly, 25 subjects performed CCT before and after cataract surgery.Results CCT scores were most reliable in the non-mydriatic condition without pinhole correction. Progressively dense brown filters produced small but significant reductions in S-cone sensitivity. Linear regression analysis of phakic subjects showed a decline for all cone classes with age. Rate of decline was greater for S-cones (slope (95% CI) = −1.09 (−1.23, 0.94)) than M-cones (slope (95% CI) = −0.80 (−0.95, −0.66)) and L-cones (slope (95% CI) = −0.66 (−0.81, - 0.52)). CCT scores increased for S-cones but reduced for L- and M-cones in pseudophakic subjects compared to phakic patients. CCT scores after cataract surgery increased for S-cones, M-cones, and L-cones by 33.0 (p<0.001), 24.9 (p=0.001), and 22.0 (p=0.008).Conclusions CCT assessment allows for clinically practical quantitation of color and contrast vision improvement after cataract surgery and aging patients who note poor vision despite good visual acuity.Translational Relevance CCT testing, historically used in research, is now a clinically practical tool to evaluate age and cataract related changes in color and contrast vision and routinely quantify vision beyond black and white visual acuity testing.Competing Interest StatementThe authors have declared no competing interest. ER -