RT Journal Article
SR Electronic
T1 Quantifying Color Vision Changes Associated with Cataracts Using Cone Contrast Thresholds
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.06.27.175570
DO 10.1101/2020.06.27.175570
A1 Urmi Mehta
A1 Anna Diep
A1 Kevin Nguyen
A1 Bryan Le
A1 Clara Yuh
A1 Caroline Frambach
A1 John Doan
A1 Ang Wei
A1 Anton M. Palma
A1 Marjan Farid
A1 Sumit Garg
A1 Sanjay Kedhar
A1 Matthew Wade
A1 Kailey A. Marshall
A1 Kimberly A. Jameson
A1 M. Cristina Kenney
A1 Andrew W. Browne
YR 2020
UL http://biorxiv.org/content/early/2020/06/28/2020.06.27.175570.abstract
AB Purpose The cone contrast threshold (CCT) test quantified color vision changes in subjects of all ages and those undergoing cataract surgery.Methods Twenty-four healthy volunteers from two cohort studies performed CCT using best corrected visual acuity, filters, mydriasis, and pinhole correction. Retrospective cross-sectional study of patients seen in eye clinics evaluated the relationship between age and color vision, and age and lens status in 355 eyes. Lastly, 25 subjects performed CCT before and after cataract surgery.Results CCT scores were most reliable in the non-mydriatic condition without pinhole correction. Progressively dense brown filters produced small but significant reductions in S-cone sensitivity. Linear regression analysis of phakic subjects showed a decline for all cone classes with age. Rate of decline was greater for S-cones (slope (95% CI) = −1.09 (−1.23, 0.94)) than M-cones (slope (95% CI) = −0.80 (−0.95, −0.66)) and L-cones (slope (95% CI) = −0.66 (−0.81, - 0.52)). CCT scores increased for S-cones but reduced for L- and M-cones in pseudophakic subjects compared to phakic patients. CCT scores after cataract surgery increased for S-cones, M-cones, and L-cones by 33.0 (p<0.001), 24.9 (p=0.001), and 22.0 (p=0.008).Conclusions CCT assessment allows for clinically practical quantitation of color and contrast vision improvement after cataract surgery and aging patients who note poor vision despite good visual acuity.Translational Relevance CCT testing, historically used in research, is now a clinically practical tool to evaluate age and cataract related changes in color and contrast vision and routinely quantify vision beyond black and white visual acuity testing.Competing Interest StatementThe authors have declared no competing interest.