PT - JOURNAL ARTICLE AU - Maxat Kulmanov AU - Senay Kafkas AU - Andreas Karwath AU - Alexander Malic AU - Georgios V Gkoutos AU - Michel Dumontier AU - Robert Hoehndorf TI - Vec2SPARQL: integrating SPARQL queries and knowledge graph embeddings AID - 10.1101/463778 DP - 2018 Jan 01 TA - bioRxiv PG - 463778 4099 - http://biorxiv.org/content/early/2018/11/07/463778.short 4100 - http://biorxiv.org/content/early/2018/11/07/463778.full AB - Recent developments in machine learning have lead to a rise of large number of methods for extracting features from structured data. The features are represented as a vectors and may encode for some semantic aspects of data. They can be used in a machine learning models for different tasks or to compute similarities between the entities of the data. SPARQL is a query language for structured data originally developed for querying Resource Description Framework (RDF) data. It has been in use for over a decade as a standardized NoSQL query language. Many different tools have been developed to enable data sharing with SPARQL. For example, SPARQL endpoints make your data interoperable and available to the world. SPARQL queries can be executed across multiple endpoints. We have developed a Vec2SPARQL, which is a general framework for integrating structured data and their vector space representations. Vec2SPARQL allows jointly querying vector functions such as computing similarities (cosine, correlations) or classifications with machine learning models within a single SPARQL query. We demonstrate applications of our approach for biomedical and clinical use cases. Our source code is freely available at https://github.com/bio-ontology-research-group/vec2sparql and we make a Vec2SPARQL endpoint available at http://sparql.bio2vec.net/.